Synthesis of the Novel Sarkosine and Proline (FK-525) Analogues of FK-506: Rearrangement of the Allylic Ester System

DOI: 10.1021/jo00307a013

Source and publish data:

Journal of Organic Chemistry p. 5448 - 5450 (1990)

Update date:2022-08-04

Topics:

Authors:

Askin, D.

Reamer, R. A.

Joe, Daisy

Volante, R. P.

Shinkai, I.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jo00307a013

The novel sarcosine 2 and proline 3 (FK-525) analogues of FK-506 have been synthesized.Allylic rearranged products not observed in the pipecolinic acid series have been isolated from the amino acid formation/macrocyclization step.

Full text of DOI:10.1021/jo00307a013

Products guided by the article

Product name:C₇₆H₁₄₇NO₁₂Si₄

Cas No:129873-39-8

R&D Labs maybe for 129873-39-8

Wuxi Innopal International Trade CO.,LTD

Contact:+86-510-80711901-8003

Address:Room 402,Building 5,Longze Garden,No.17,South huanjiu Road,Yixing City, Jiangsu,China
Hangzhou innopharma technology Co,.Ltd.(expird)

Contact:+86-13388601988

Address:Room845,lixin building, moganshan road, hangzhou, china
zhuzhou zhongle chemical co. ltd.

Contact:+86-0731 28228409

Address:Zhuzhou, Hunan, China
Shanghai better-in Medical Technology Co.,LTD.

Contact:+86-21-38921049

Address:Lane 720 zhangjianggaoke cailun road, Pudong, Shanghai, room 513
Hubei Lingsheng Pharmaceuticals Co., Ltd.

Contact:+86-0710-3538058

Address:Xiangyang City Xiangcheng Economic Development Zone, Hubei Province

Relevant to this article

Efficient heck reactions catalyzed by palladium(0) and -(II) complexes bearing n-heterocyclic carbene and amide functionalities

Doi:10.1021/om1006402
(2010)
Electrochemical C?H/N?H Functionalization for the Synthesis of Highly Functionalized (Aza)indoles

Doi:10.1002/anie.201602616
(2016)
Synthesis of Enantiomerically Pure 1-Methyl-2-alkenyl N,N-Diisopropylcarbamates from (S)- or (R)-Lactates

Doi:10.1055/s-1990-26855
(1990)
Novel class of amino acid antagonists at non-N-methyl-D-aspartic acid excitatory amino acid receptors. Synthesis, in vitro and in vivo pharmacology, and neuroprotection

Doi:10.1021/jm00105a019
(1991)
4,6-Dimethoxy-1,3,5-triazine oligoxyloglucans: Novel one-step preparable substrates for studying action of endo-β-1,4-glucanase III from Trichoderma reesei

Doi:10.1016/j.bmcl.2010.04.122
(2010)
Rational investigations in the ring opening of cyclic carbonates by amines

Doi:10.1039/c4gc01032a
(2014)

Article Doi