Synthesis of the Novel Sarkosine and Proline (FK-525) Analogues of FK-506: Rearrangement of the Allylic Ester System

DOI: 10.1021/jo00307a013

Source and publish data:

Journal of Organic Chemistry p. 5448 - 5450 (1990)

Update date:2022-08-04

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Authors:

Askin, D.

Reamer, R. A.

Joe, Daisy

Volante, R. P.

Shinkai, I.

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Article abstract of DOI:10.1021/jo00307a013

The novel sarcosine 2 and proline 3 (FK-525) analogues of FK-506 have been synthesized.Allylic rearranged products not observed in the pipecolinic acid series have been isolated from the amino acid formation/macrocyclization step.

Full text of DOI:10.1021/jo00307a013

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