The Chemistry of Phthalide-3-carboxylic Acid. VII Reaction with Isoquinoline Derivatives

DOI: 10.1071/CH9900375

Source and publish data:

Australian Journal of Chemistry p. 375 - 381 (1990)

Update date:2022-08-05

Topics:

Authors:

Donati, Cosimo

Hung, Tran V.

Prager, Rolf H.

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Article abstract of DOI:10.1071/CH9900375

Phthalide-3-carboxylic acid has been decarboxylated in the presence of isoquinoline, 1-chloroisoqinoline and isoquinoline N-oxides to give low yields of compounds resulting from alkylation of the isoquinoline heterocycle at C1 with a phthalidyl group.Attempted Barton decarboxylation-alkylation in the presence of isoquinolinium salts was unsuccessful.

Full text of DOI:10.1071/CH9900375

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