Highly Stereoselective Access to an (E)-Vinyl Bromide from an Aryl Ketone Leads to Short Syntheses of (Z)-Tamoxifen and Important Substituted Derivatives

DOI: 10.1021/jo00312a027

Source and publish data:

Journal of Organic Chemistry p. 6184 - 6187 (1990)

Update date:2022-09-26

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Authors:

Potter, Gerard A.

McCague, Raymond

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Article abstract of DOI:10.1021/jo00312a027

The enol triflate derived from a 1-(4-alkoxyphenyl)-2-phenyl-1-butanone is unstable, fragmenting to a vinyl cation that can be trapped by bromide ion.The E isomer of the vinyl bromide which is formed in preference (20:1) gave, upon palladium-catalyzed cou

Full text of DOI:10.1021/jo00312a027

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