A novel synthesis of both enantiomers of α-hydroxycarboxylic esters and amides from (-)-1-chlorobutyl p-tolyl sulfoxide

Article abstract of DOI:10.1016/S0040-4039(00)94444-7

Addition of the carbanion of (-)-1-chlorbutyl p-tolyl sulfoxide to aldehydes gave two adducts, which were converted to both enantiomers of α-hydroxycarboxylic esters or amides in two steps in high overall yields.