Stereospecific synthesis, assignment of absolute configuration, and biological activity of the enantiomers of 3-[[[3-[2-(7-chloroquinolin-2-yl)-(E)-ethenyl]phenyl][[3-(dimethylami no)-3-oxopropyl]thio]methyl]thio]propionic acid, a potent and specific leuk

DOI: 10.1021/jm00172a025

Source and publish data:

Journal of Medicinal Chemistry p. 2841 - 2845 (1990)

Update date:2022-07-30

Topics:

Authors:

Gauthier

Jones Jones

Champion

Charette

Dehaven Dehaven

Ford-Hutchinson

Hoogsteen

Lord Lord

Masson Masson

Piechuta

Pong Pong

Springer

Therien Therien

Zamboni Zamboni

Young Young

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Article abstract of DOI:10.1021/jm00172a025

The enantiomers of the leukotriene D₄ antagonist 3-[[[3-[2-(7-chloroquin-2-yl)-(E)-ethenyl]phenyl][[3-(dimethylamino)- 3-oxopropyl]thio]methyl]thio]propionic acid (L-660,711)(MK-571) have been prepared, their absolute stereochemistry has been a

Full text of DOI:10.1021/jm00172a025

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