Synthesis of enantiomerically pure precursors of carbapenems from carbohydrates

Article abstract of DOI:10.1016/S0040-4039(00)98815-4

Conjugate addition-rearrangement of N-p-metoxybenzylhydroxylamine to α,β-unsaturated sugar lactones followed by hydrogenolysis of the O-N bond in isoxazolidin-5-ones, and subsequent cyclization of the resulting β-amino acid, provides an effective route to