N -(3-Fluoro-4-(4-(2-methoxy or 2,3-dichlorophenyl)piperazine-1-yl)butyl) arylcarboxamides as selective dopamine D3 receptor ligands: Critical role of the carboxamide linker for d3 receptor selectivity

DOI: 10.1021/jm200288r

Source and publish data:

Journal of Medicinal Chemistry p. 3581 - 3594 (2011)

Update date:2022-08-05

Topics:

Authors:

Banala, Ashwini K.

Levy, Benjamin A.

Khatri, Sameer S.

Furman, Cheryse A.

Roof, Rebecca A.

Mishra, Yogesh

Griffin, Suzy A.

Sibley, David R.

Luedtke, Robert R.

Newman, Amy Hauck

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Article abstract of DOI:10.1021/jm200288r

N-(3-Fluoro-4-(4-(2,3-dichloro- or 2-methoxyphenyl)piperazine-1-yl)butyl) arylcarboxamides were prepared and evaluated for binding and function at dopamine D3 receptors (D3Rs) and dopamine D2 receptors (D2Rs). In this series, we discovered some of the mos

Full text of DOI:10.1021/jm200288r

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