Highly Regioselective Monoalkylation of Ketones via Manganese Enolates. Prepared from Lithium Enolates

Article abstract of DOI:10.1016/S0040-4039(00)76830-4

Li-enolates are readily converted to Mn-enolates by treatment with manganese halides.In THF, the reaction is easily and economically performed with manganese chloride at room temperature.Mn-enolates can then be regioselectively monoalkylated in good yields.The formation of di and polyalkylated products is never observed (<1percent).