Synthesis of a chemically and metabolically stable and biologically potent PGD2-analogue

Article abstract of DOI:10.1016/S0040-4039(00)97413-6

The metabolic labile α-chain of the PGD₂-analogue 2 (ZK 110841) can be stabilized by introduction of an β-oxygen-atom resulting in 3 (ZK 118182), which has a much higher and longer lasting biological activity on oral application in rats. The synthetic methodology for the synthesis of 3-oxa-Z-Δ^5,6-prostaglandins will be discussed.