Journal of Medicinal Chemistry p. 2590 - 2595 (1990)
Update date:2022-09-26
Topics:
Saari, Walfred S.
Schwering, John E.
Lyle, Paulette A.
Smith, Steven J.
Engelhardt, Edward L.
Some 3'- and 5'-<<(alkylamino)ethyl>glycyl> esters of 5-bromo-2'-deoxyuridine were prepared and evaluated in vitro as progenitors of the parent alcohol.The sters proved to be relatively stable at low pH but released 5-bromo-2'-deoxyuridine cleanly at rates which were pH and structure dependent.These basic esters are examples of cyclization-activated prodrugs in which generation of active drug is not linked to enzymatic cleavage but rather results from an intramolecular cyclization-elimination reaction.
View MoreShanghai Yingrui Biopharma Co., Ltd
Contact:021-3358 8661*8003
Address:shanghai
website:http://www.antimex.com
Contact:0086-21-50563169
Address:Room1027,No.Jinyu Road,Pudong
HENAN NEW BLUE CHEMICAL CO.,LTD
website:http://www.newbluechem.com
Contact:86-371-55170693/55170694
Address:Zhengzhou International Trade New Territory,Jinshui District,Zhengzhou ,China
Frapp's Chemical (NFTZ) Co.,Ltd
Contact:+86-576-86137892
Address:General Chamber of Commercial Building, 159 Wanchang Middle Road, Wenling, Zhejiang, China
Contact:86-21-68404353-215
Address:Rm 710, 30 BLDG, 2419 Hu Nan RD., Pudong New Area, Shanghai, China
Doi:10.1016/0008-6215(90)80018-X
(1990)Doi:10.1002/anie.201915962
(2020)Doi:10.1021/ja00178a037
(1990)Doi:10.1016/S0040-4039(00)94494-0
(1990)Doi:10.1016/j.jfluchem.2011.02.003
(2011)Doi:10.1039/c003597a
(2010)
