N-(Dialkylamino-2 ethyl) 2,3-dihydro 1,4-benzodioxin 2-carboximidamides-2: Synthesis and pharmacological activities

Article abstract of DOI:10.1016/0223-5234(90)90002-K

In connection with the structure of piperoxan 1 and the recently described pharmacological properties of N-(diethylamino-2 ethyl) 2,3-dihydro 1,4-benzodioxin 2-carboximidamide 2a (R = C₂H₅, R' = H) and of idazoxan 3, different structural analogues have been prepared. These derivatives showed marked antiarrhythmic properties leading to the disappearance of extrasystoles and to a persistent regularization of the cardiac rhythm of rabbits perfused with aconitine. In addition, sedative effects have been detected using classical tests.