SYNTHESIS OF A 4-HELIX BUNDLE-LIKE TEMPLATE-ASSEMBLED SYNTHETIC PROTEIN (TASP) BY CONDENSATION OF A PROTECTED PEPTIDE ON A CONFORMATIONALLY CONSTRAINED CYCLIC CARRIER

Article abstract of DOI:10.1016/S0040-4039(00)94486-1

We describe the condensation in solution of a fully protected helix model peptide to a cyclic peptide template including a new turn-inducing mimic to obtain a 4-helix bundle protein-like TASP.This approach allows the total synthesis of chemically and structurally well-defined protein models in the 6-10 kDa range.