A SYNTHESIS OF (R)-(-)-MEVALONOLACTONE BY THE COMBINATION OF ENZYMATIC AND CHEMICAL METHODS

DOI: 10.1016/S0040-4020(01)81516-7

Source and publish data:

Tetrahedron p. 3463 - 3468 (1990)

Update date:2022-08-05

Topics:

Authors:

Sugai, Takeshi

Kakeya, Hideaki

Ohta, Hiromichi

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Article abstract of DOI:10.1016/S0040-4020(01)81516-7

(R)-(-)-Mevalonolactone was synthesized starting from a chiral tertiary α-benzyloxy ester, obtained by the lipase-catalyzed enantioselective hydrolysis of the corresponding racemate, in 7 steps and 21.5percent overall yield.Intramolecular Friedel-Crafts r

Full text of DOI:10.1016/S0040-4020(01)81516-7

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