Hydrolysis and acyl migration of a catechol monoeter of L-dopa: L-3-(3-hydroxy-4-pivaloyloxyphenyl)alanine

Article abstract of DOI:10.1002/jps.2600790811

Hydrolysis and acyl migration studies on L-3-(3-hydroxy-4-pivaloyloxyphenyl)alanine (1, NB-355), which produced long-lasting plasma L-dopa levels after oral dosing, have been conducted. Compound 1 exists as pure 4-O-pivaloyl-L-dopa in the solid state, but