The stereoselective first total synthesis of isoschizandrin having the natural configuration

Article abstract of DOI:10.1016/S0957-4166(00)80159-7

The total synthesis of isoschizandrin 1 having the natural configuration was accomplished confirming the structure of 1 in unambiguous manner. Starting from optically pure 9, allylic alcohol 11 was obtained in good yield, and was then converted into epoxide 12 stereoselectively. Finally, reductive C-O bond fission afforded the natural enantiomer of isoschizandrin 1.