KINETIC RESOLUTION OF RACEMIC GRIGNARD REAGENTS BY NICKEL-CATALYZED ASYMMETRIC GRIGNARD CROSS-COUPLING

DOI: 10.1016/0040-4039(81)80169-4

Source and publish data:

Tetrahedron Letters p. 137 - 140 (1981)

Update date:2022-08-05

Topics:

Authors:

Hayashi, Tamio

Kanehira, Koichi

Hioki, Tsuyoshi

Kumada, Makoto

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Article abstract of DOI:10.1016/0040-4039(81)80169-4

Racemic Grignard reagents, 2-phenylpropylmagnesium chloride and 2-norbornylmagnesium chloride were kinetically resolved by asymmetric cross-coupling with vinyl bromides in the presence of chiral phosphine-nickel catalysts to give optically active coupling products (ca. 37percent ee) and carboxylic acids after carbonation with carbon dioxide.

Full text of DOI:10.1016/0040-4039(81)80169-4

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