Asymmetric Suzuki-Miyaura cross-coupling of aryl chlorides with enhancement of reaction time and catalyst turnover

Article abstract of DOI:10.1016/j.tetlet.2011.03.051

A series of new chiral phosphonite ligands were evaluated for the palladium-catalyzed asymmetric Suzuki-Miyaura cross-coupling reactions of aryl chlorides. Ligand 4 gave 91% yield and 78% ee with 0.5 mol % catalyst loading for the coupling of aryl boronic