SYNTHESIS OF 2-AMINO-2-CHROMENES
265
conditions (Scheme 2). The corresponding 2-amino-chromene
derivatives were obtained in good to high yields (Table 2).
The results obtained with benzaldehyde, malononitrile and
1-naphthol under the optimized conditions were compared with
the best ones published so far for this reaction using inorganic
or organic alkali catalysts; the data is listed in Table 3. It showed
that the piperazine was fairly a good catalyst for this reaction.
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CONCLUSION
In summary, we have developed a simple and efficient
methodology for the synthesis of 2-amino-chromene derivatives
by a one-pot, multi-component reaction. Some advantageous of
this solvent-free protocol include a simple reaction set-up, high
products yields, short reaction times, and elimination of toxic
solvents.
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