Synthesis of α-CN and α-CF3 N-heterocycles through tandem nucleophilic additions

Article abstract of DOI:10.1021/ol2011902

Using a readily available secondary aminoalkyne as starting material, a powerful strategy was discovered to prepare precursors of biologically important unnatural cyclic aminoacids and fluorinated N-heterocycles with important ring sizes (e.g., 5-7) in a