Quinazoline antifolates inhibiting thymidylate synthase: 4-thio-substituted analogues

DOI: 10.1021/jm00107a015

Source and publish data:

Journal of Medicinal Chemistry p. 978 - 984 (1991)

Update date:2022-09-26

Topics:

Authors:

Thornton

Jones Jones

Jackman Jackman

Flinn Flinn

O'Connor

Warner Warner

Calvert Calvert

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00107a015

We report the synthesis of four new 4-thio-5,8-dideazafolic acid analogues and a 4-(methylthio) analogue structurally related to the thymidylate synthase (TS) inhibitor N¹⁰-propargyl-5,8-dideazafolic acid. Three N¹⁰-propargyl-4-thio-

Full text of DOI:10.1021/jm00107a015

Products guided by the article

Product name:6-(dibromomethyl)-2-(pivaloylamino)-4-(methylthio)quinazoline

Cas No:131066-80-3

R&D Labs maybe for 131066-80-3

Shijiazhuang Haitian Amino Acid Co., Ltd.

Contact:+86-311-88908111

Address:Shijiazhuang Hebei province,China
Suzhou Sibian Chemical Technology Co., Ltd

website:http://www.sibianpharm.com

Contact:+8618169181984,+8618013186906

Address:Room1404,BuildingA,Jiabao Square No.323 Baodai East Road,Wuzhong District,Suzhou Jiangsu China (215128)
Shandong Bolode Bio-Technology Co., LTD

Contact:+86-0531-58966870

Address:136 Jingyi Road,Huaiyin District,Jinan,Shandong,China
Dongtai Xinyuan Chemical Co., Ltd.

Contact:+86-21-56733000

Address:404F, 99Nong No.117 Zhongtan Rd. Shanghai
Tocopharm Co., Ltd.

Contact:+86-021-6989-5597

Address:No.80 Yichuan Rd., Putuo District,Shanghai,P.R.China

Relevant to this article

Synthesis and characterization of a symmetric bis(7-hydroxyflavylium) containing a methyl viologen bridge

Doi:10.1002/chem.201003726
(2011)
Cellular Localisation of Antitumoral 6-Alkyl Thymoquinones Revealed by an Alkyne-Azide Click Reaction and the Streptavidin-Biotin System

Doi:10.1002/cbic.201000762
(2011)
Coordination-assembly for quantitative construction of bis-branched molecular shuttles

Doi:10.1039/c0ob01124j
(2011)
Isolation of a bis-iodurated tetra-THF as a trace product from the oxidation of squalene with RuO₄ and its double ring expansion to a novel bis-THF-bis-THP compound

Doi:10.3390/molecules16075362
(2011)
5′-Epimeric 3′-deoxy-3′,4′-didehydronucleoside- 5′-C-phosphonates: Synthesis and structural assignment by NMR and X-ray analyses

Doi:10.1016/j.tet.2011.04.037
(2011)
Synthesis of structural elements of the capsular polysaccharides of Streptococcus pneumoniae types 6A and 6B

Doi:10.1016/0008-6215(90)84051-U
(1990)

Article Doi