Quinazoline antifolates inhibiting thymidylate synthase: 4-thio-substituted analogues

DOI: 10.1021/jm00107a015

Source and publish data:

Journal of Medicinal Chemistry p. 978 - 984 (1991)

Update date:2022-09-26

Topics:

Authors:

Thornton

Jones Jones

Jackman Jackman

Flinn Flinn

O'Connor

Warner Warner

Calvert Calvert

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Article abstract of DOI:10.1021/jm00107a015

We report the synthesis of four new 4-thio-5,8-dideazafolic acid analogues and a 4-(methylthio) analogue structurally related to the thymidylate synthase (TS) inhibitor N¹⁰-propargyl-5,8-dideazafolic acid. Three N¹⁰-propargyl-4-thio-

Full text of DOI:10.1021/jm00107a015

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Product name:6-(dibromomethyl)-2-(pivaloylamino)-4-(methylthio)quinazoline

Cas No:131066-80-3

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