Organic Letters p. 3596 - 3599 (2011)
Update date:2022-08-02
Topics: Chemoselective Trifluoromethylation Electrophilic Cu-mediated
Kawai, Hiroyuki
Furukawa, Tatsuya
Nomura, Yoshinori
Tokunaga, Etsuko
Shibata, Norio
Copper-mediated chemoselective trifluoromethylation at the benzylic position by the use of shelf-stable electrophilic trifluoromethylating reagents 3 in good to high yields under mild conditions is described for the first time. The generality of this trifluoromethylation for a wide variety of benzyl bromides facilitates the rapid creation of structural diversity of medicinal candidates in drug discovery.
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