Active-Site-Directed Modification of Subtilisin

DOI: 10.1021/ja00006a052

Source and publish data:

Journal of the American Chemical Society p. 2259 - 2263 (1991)

Update date:2022-08-05

Topics:

Authors:

Zhong, Ziyang

Bibbs, Jeffrey A.

Yuan, Wei

Wong, Chi-Huey

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Article abstract of DOI:10.1021/ja00006a052

This paper describes the development of several competitive inhibitors and mechanism-based inactivators of subtilisin BPN′. Various methyl arylakanesulfonates were prepared and shown to be either competitive inhibitors or selective methylating reagents fo

Full text of DOI:10.1021/ja00006a052

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