N-aryl pyrazoles: DFT calculations of CH acidity and deprotonative metallation using a combination of lithium and zinc amides

DOI: 10.1039/c1ob05267e

Source and publish data:

Organic and Biomolecular Chemistry p. 4671 - 4684 (2011)

Update date:2022-08-04

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Authors:

Chevallier, Floris

Halauko, Yury S.

Pecceu, Christelle

Nassar, Ibrahim F.

Dam, To Uyen

Roisnel, Thierry

Matulis, Vadim E.

Ivashkevich, Oleg A.

Mongin, Florence

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Article abstract of DOI:10.1039/c1ob05267e

A series of N-aryl and N-heteroaryl pyrazoles have been deproto-metallated using a 2,2,6,6-tetramethylpiperidino-based mixed lithium-zinc combination. Mono-, di-, and tri-iodides have been obtained after subsequent trapping with iodine, depending on the s

Full text of DOI:10.1039/c1ob05267e

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