From 4,5,6,7-tetrahydroindole to functionalized furan-2-one-4,5,6,7- tetrahydroindole-cyclobutene sequence in two steps

DOI: 10.1016/j.tet.2011.05.018

Source and publish data:

Tetrahedron p. 4832 - 4837 (2011)

Update date:2022-08-02

Topics:

Authors:

Sobenina, Lyubov N.

Stepanova, Zinaida V.

Ushakov, Igor A.

Mikhaleva, Al'Bina I.

Tomilin, Denis N.

Kazheva, Ol'Ga N.

Alexandrov, Grigorii G.

Dyachenko, Oleg A.

Trofimov, Boris A.

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Article abstract of DOI:10.1016/j.tet.2011.05.018

Ethyl 3-(4,5,6,7-tetrahydroindol-2-yl)propynoate, readily available from 4,5,6,7-tetrahydroindole and ethyl bromopropynoate, when treated with dichlorodicyanobenzoquinone (DDQ) in methanol affords furan-2-one-4,5,6,7- tetrahydroindole-cyclobutene sequence

Full text of DOI:10.1016/j.tet.2011.05.018

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Product name:diethyl 7-(1-benzyl-4,5,6,7-tetrahydro-1H-indol-2-yl)-3-chloro-1,5-dicyano-4-oxobicyclo[3.2.0]hepta-2,6-diene-2,6-dicarboxylate

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