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COMMUNICATION
enables the synthesis of biaryl ketones in high yields with high
selectivities. Importantly, the operationally simple method has
been succesfully applied to the synthesis of the marketed drug
Fenofibrate, and a complex druglike molecule. Studies to
expand this transition-metal-free carbonylation process to other
carbonylative cross-couplings as well as elucidate the detailed
mechanism are ongoing.
The work was sponsored by the Natural Science Foundation
of China (21302099), the Natural Science Foundation of
Jiangsu Province (BK2012449), the SRF for ROCS, SEM, and
the Priority Academic Program Development of Jiangsu Higher
Education Institutions.
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Jiangsu Collaborative Innovation Center of Biomedical Functional
Materials, Jiangsu Key Laboratory of Biofunctional Materials, Key
Laboratory of Applied Photochemistry, School of Chemistry and
Materials Science, Nanjing Normal University, Wenyuan Road No.1,
210023 Nanjing (China)
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