Studies on the synthesis of C-glycoside sulfones as potential glycosyl transferase inhibitors

Article abstract of DOI:10.1016/S0040-4020(97)01021-1

β-C-Glycoside sulfoxides and sulfones were prepared by radical addition of thiol acetic acid to exocyclic glycals followed by deacetylation, S-alkylation, and selective oxidation. These compounds are representative examples of a new class of molecules designed to be glycosyl transferase inhibitors.