Synthesis and Resolution of (+/-)-7-Chloro-8-hydroxy-1-(3'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine (TISCH): A High Affinity and Selective Iodinated Ligand for CNS D1 Dopamine Receptor

DOI: 10.1021/jm00107a002

Source and publish data:

Journal of Medicinal Chemistry p. 877 - 883 (1991)

Update date:2022-08-02

Topics:

Authors:

Chumpradit, Sumalee

Kung, Mei-Pung

Billings, Jeffrey J.

Kung, Hank F.

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Article abstract of DOI:10.1021/jm00107a002

The synthesis and resolution of (+/-)-7-chloro-8-hydroxy-1-(3'-iodophenyl)-3-methyl-2,3,4,5-tetrahydro-1H-3-benzazepine, (+/-)-TISCH (8) has been achieved by resolution of intermediate 4, the O-methoxyl, 3'-bromo derivative, as the diastereomeric camphor

Full text of DOI:10.1021/jm00107a002

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