
Tetrahedron Letters p. 3637 - 3640 (1990)
Update date:2022-08-02
Topics:
Machinaga, Nobuo
Kibayashi, Chihiro
The enantiodivergent total synthesis of (+)-(2S,5S)- and (-)-(2R,5R)-trans-2-butyl-5-pentylpyrrolidines was effected from the C2 symmetric (S,S)- and (R,R)-diepoxides, respectively, both prepared from D-mannitol, by a sequence involving stereo-defined ring construction of the unsymmetrical trans-2,5-dialkylpyrrolidine via the cyclic sulfate as a key step.
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