Heterocyclic Communications p. 363 - 366 (2008)
Update date:2022-07-29
Topics:
Sailu
Ramakrishna
Komaraiah
Reddy
The sulfide intermediate, (′2-[[[3-Methyl-4- (2,2,2-trifluoroethoxy)- 2-pyridinyl] methyl] thio]-1H-benzimidazole) (3), required for the industrial synthesis of the anti-ulcer drug Lansoprazole, has been prepared in excellent yields by microwave irradiation of a dry mixture of 2-chloromethyl-3-methyl-4- (2,2,2-trifluoroethoxy)pyridine hydrochloride (1) and 2-mercaptobenzimidazole (2) in the presence of Na2CO3.
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