THERMAL REARRANGEMENT OF THE IMMUNOSUPPRESSANT FK-506

DOI: 10.1016/S0040-4039(00)97095-3

Source and publish data:

Tetrahedron Letters p. 6477 - 6480 (1990)

Update date:2022-08-03

Topics:

Authors:

Ok, H. Ok, H.

Arison, B. H.

Ball, R. G.

Beatti, T. R.

Fisher, M. H.

Wyvratt, M. J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)97095-3

Treatment of FK-506 in xylene at reflux results in a <3,3> sigmatropic rearrangement of the allylic ester portion of the molecule to give a new ring expanded macrolide.

Full text of DOI:10.1016/S0040-4039(00)97095-3

Products guided by the article

Product name:(13E,16E,20E)-(1R,9S,12R,15R,19S,23S,25S,26R,27S,29R)-19-Allyl-1-hydroxy-12-((1R,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-25,27-dimethoxy-13,15,21,23,29-pentamethyl-11,30-dioxa-4-aza-tricyclo[24.3.1.0^4,9]triaconta-13,16,20-triene-2,3,10,18-tetraone

Cas No:131944-49-5

R&D Labs maybe for 131944-49-5

SHAANXI FUJIE PHARMACEUTICAL CO.,LTD

website:http://www.fujiepharm.com

Contact:+86-29-63650906

Address:Yuanqu Yi Road, Qinghe Food Industrial Park, Sanyuan County, Shaanxi Province, China
Chemsigma International Co.,Ltd.

website:http://www.chemsigma.com

Contact:86-025-58748998

Address:Rm.705, 15th Building,Rd.Xinke II
jintan yufan Medicine Raw materials Co.,Ltd.(expird)

Contact:86-519-82808282

Address:6th,Jincheng Huangzhuang
Hubei Danao Pharmaceutical Co.,Ltd.

website:http://www.danaopharm.com

Contact:+86-719-5251167

Address:Fandan Road,Danjiangkou,Hubei
Jiangxi Hito Chemical Co., Ltd.

Contact:+86-792-3170318

Address:No. 6, Tianhong Ave., Xinghuo Industry Park, Yongxiu, Jiujiang, Jiangxi, China

Relevant to this article

Synthesis of triazoles, oxadiazoles and condensed heterocyclic compounds containing cinchopheny and studies on biological activity of representative compounds

Doi:10.1002/jccs.200400049
(2004)
Potential Antitumor Agents. 62. Structure Activity Relationships for Tricyclic Compounds Related to the Colon Tumor Active Drug 9-Oxo-9H-xanthene-4-acetic Acid

Doi:10.1021/jm00106a003
(1991)
One-Pot Tandem Assembly of Amides, Amines, and Ketones: Synthesis of C4-Quaternary 3,4- And 1,4-Dihydroquinazolines

Doi:10.1021/acs.joc.0c01308
(2020)
Formation of a manganese alkyl complex as an intermediate in the ring-opening hydroformylation of α-cyclopropylstyrene by HMn(CO)5

Doi:10.1016/0022-328X(92)83184-J
(1992)
Total synthesis of 10-isocyano-4-cadinene and its stereoisomers and evaluations of antifouling activities

Doi:10.1021/jo2008109
(2011)
Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide

Doi:10.1016/j.bmcl.2011.05.099
(2011)

Article Doi