THERMAL REARRANGEMENT OF THE IMMUNOSUPPRESSANT FK-506

DOI: 10.1016/S0040-4039(00)97095-3

Source and publish data:

Tetrahedron Letters p. 6477 - 6480 (1990)

Update date:2022-08-03

Topics:

Authors:

Ok, H. Ok, H.

Arison, B. H.

Ball, R. G.

Beatti, T. R.

Fisher, M. H.

Wyvratt, M. J.

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Article abstract of DOI:10.1016/S0040-4039(00)97095-3

Treatment of FK-506 in xylene at reflux results in a <3,3> sigmatropic rearrangement of the allylic ester portion of the molecule to give a new ring expanded macrolide.

Full text of DOI:10.1016/S0040-4039(00)97095-3

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