THERMAL REARRANGEMENT OF THE IMMUNOSUPPRESSANT FK-506

DOI: 10.1016/S0040-4039(00)97095-3

Source and publish data:

Tetrahedron Letters p. 6477 - 6480 (1990)

Update date:2022-08-03

Topics:

Authors:

Ok, H. Ok, H.

Arison, B. H.

Ball, R. G.

Beatti, T. R.

Fisher, M. H.

Wyvratt, M. J.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0040-4039(00)97095-3

Treatment of FK-506 in xylene at reflux results in a <3,3> sigmatropic rearrangement of the allylic ester portion of the molecule to give a new ring expanded macrolide.

Full text of DOI:10.1016/S0040-4039(00)97095-3

Products guided by the article

Product name:(13E,16E,20E)-(1R,9S,12R,15R,19S,23S,25S,26R,27S,29R)-19-Allyl-1-hydroxy-12-((1R,3R,4R)-4-hydroxy-3-methoxy-cyclohexyl)-25,27-dimethoxy-13,15,21,23,29-pentamethyl-11,30-dioxa-4-aza-tricyclo[24.3.1.0^4,9]triaconta-13,16,20-triene-2,3,10,18-tetraone

Cas No:131944-49-5

R&D Labs maybe for 131944-49-5

Haitong Chemical Industrial Co.,Ltd.

website:https://www.haitonglongwin.com/

Contact:+86-022-66221018

Address:18-701, No.99, The 4th Street, TEDA,
Zhejiang Genebest Pharmaceutical Co.,Ltd.

Contact:0086-571-63532866

Address:No.1 Jinboshi Rd Lishan Town Fuyang City Zhejiang Province China
Shanghai Yuanye Bio-Technology Co., Ltd.

website:http://www.shyuanye.com

Contact:+86-21-61845781

Address:Building 6, No. 465, Changta Road,Songjiang District,Shanghai,China
Shanghai Hohance Chemical Co., ltd

Contact:13914753421

Address:Fl.5；Bld. 70, Lane 1500; Xinfei Road
HaiNan Periwinkle Pharmaceutical Co.,Ltd.

website:http://www.cchpharm.com/en/index.html

Contact:020-82208978

Address:Gongye road,Wuzhishan city,HaiNan province

Relevant to this article

Synthesis of triazoles, oxadiazoles and condensed heterocyclic compounds containing cinchopheny and studies on biological activity of representative compounds

Doi:10.1002/jccs.200400049
(2004)
Potential Antitumor Agents. 62. Structure Activity Relationships for Tricyclic Compounds Related to the Colon Tumor Active Drug 9-Oxo-9H-xanthene-4-acetic Acid

Doi:10.1021/jm00106a003
(1991)
One-Pot Tandem Assembly of Amides, Amines, and Ketones: Synthesis of C4-Quaternary 3,4- And 1,4-Dihydroquinazolines

Doi:10.1021/acs.joc.0c01308
(2020)
Formation of a manganese alkyl complex as an intermediate in the ring-opening hydroformylation of α-cyclopropylstyrene by HMn(CO)5

Doi:10.1016/0022-328X(92)83184-J
(1992)
Total synthesis of 10-isocyano-4-cadinene and its stereoisomers and evaluations of antifouling activities

Doi:10.1021/jo2008109
(2011)
Discovery of microsomal triglyceride transfer protein (MTP) inhibitors with potential for decreased active metabolite load compared to dirlotapide

Doi:10.1016/j.bmcl.2011.05.099
(2011)

Article Doi