Tetrahedron p. 13837 - 13866 (1996)
Update date:2022-08-03
Topics:
Bennani, Youssef L.
Hanessian, Stephen
The design, preparation, structural and spectroscopic analyses of topologically unique and enantiomerically pure alkyl phosphonamides are described. In the case of α-ethyl and α-benzyl phosphonamides, the geometry of both the secondary and tertiary carbanions was determined to be planar through deprotonation/deuteration/alkylation experiments. Stereoselective alkylations of such systems proceeded in good yields and with high diastereoselectivities. The resulting α,α-alkylated phosphonamides were hydrolyzed to give the corresponding α,α-alkyl phosphonic acids with high degrees of enantiomeric purity.
View Morewebsite:http://www.lonwinchem.com
Contact:Tel: 86-21-59858395
Address:No#966,Huaxu Road,Shanghai 201702,P.R.China
Contact:+44 (0)2036089360-31
Address:Chanceryhouse,Chancery Lan
Chiral Quest (Suzhou) Company Ltd
website:http://www.chiralquest.com
Contact:+86-0512-62956066
Address:B1/9, 218 Xinghu Street, Suzhou Industrial Park
Dongtai Xinyuan Chemical Co., Ltd.
Contact:+86-21-56733000
Address:404F, 99Nong No.117 Zhongtan Rd. Shanghai
Suqian Ruixing Chemical Co., Ltd.
Contact:+86-527-80805666(总机);84836008(销售)
Address:3 Jingsilu, Zone north, Hubin Xincheng Development Park, Suqian, China
Doi:10.1016/S0040-4020(01)90063-8
(1990)Doi:10.1002/anie.201008212
(2011)Doi:10.1021/jo201191x
(2011)Doi:10.1016/j.bmcl.2011.06.009
(2011)Doi:10.1039/P19900003113
(1990)Doi:10.1055/s-0030-1259973
(2011)