Convenient alkylation of 6,7-dihydro-7-phenyl-5H-pyrrolo[3,4-b]pyridin5- ones in a phase transfer system. Synthesis of novel cyclic nicotinamide analogs

Article abstract of DOI:10.1246/bcsj.63.3047

The title reaction is readily achieved with alkyl halides in the presence of sodium hydroxide and a phase transfer catalyst to afford 7-alkylated derivatives in good yields. The present reaction involving intramolecular double-alkylation at C-7 and N-6 wi