A versatile asymmetric synthesis of α-amino α-alkyl-phosphonic acids of high enantiomeric purity

Article abstract of DOI:10.1016/S0040-4039(00)97092-8

A general protocol for the synthesis of α-amino-α- alkyl phosphonic acids in either enantiomeric form is described based on the alkylation of chiral bicyclic phosphonamides derived from (R,R)- and (S,S)-1,2-diaminocyclohexane.