Asymmetric hydroformylation catalyzed by an Rh( I) -( R,S) -BINAPHOS complex: Substituent effects in olefins on the regioselectivity

Article abstract of DOI:10.1016/S0022-328X(96)06620-X

Olefins bearing the larger substituants at the allylic position were hydroformylated in the higher iso/normal selectivity when Rh(I)-(R,S)-BINAPHOS was used as a catalyst. Deuterioformylation of 4,4,4-triphenyl-1 -butene suggests that the higher iso/normal ratio may be attributed to the accelerated CO insertion to the iso-alkylrhodium 7i.