European Journal of Medicinal Chemistry p. 203 - 211 (2019)
Update date:2022-08-05
Topics:
Su, Liqiang
Li, Jiahui
Zhou, Zhen
Huang, Dongxia
Zhang, Yuanjin
Pei, Haixiang
Guo, Weikai
Wu, Haigang
Wang, Xin
Liu, Mingyao
Yang, Cai-Guang
Chen, Yihua
Several 6-substituted tetrahydrocarbazole derivatives were designed, synthesized and evaluated for the antibacterial activities against Staphylococcus aureus Newman strain. Subsequently, 2,4-diaminopyrimidine scaffold was merged with the tetrahydrocarbazole unit to generate a series of novel hybrid derivatives and the antibacterial activities were also investigated. Among these novel hybrids, compound 12c showed the most potent activity with a MIC of 0.39–0.78 μg/mL against S. aureus Newman and Escherichia coli AB1157 strain. In addition, compound 12c exhibited low MIC values against a panel of multidrug-resistant strains of S. aureus.
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