Mimicking of Ergot Alkaloids and Synthetic Piperidine Drugs by 2,5-Substituted Piperidines Derived from Cis and Trans Ethyl 1-Benzyl-6-Cyano-3-Piperidinecarboxylate.

DOI: 10.1016/S0040-4020(01)81192-3

Source and publish data:

Tetrahedron p. 9753 - 9766 (1992)

Update date:2022-08-05

Topics:

Authors:

Branden, Stefan Van den

Compernolle, Frans

Hoornaert, Georges J.

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Article abstract of DOI:10.1016/S0040-4020(01)81192-3

This report describes the synthesis of pharmacologically interesting 2,5-substituted piperidines from cis and trans ethyl 1-benzyl-6-cyano-3-piperidinecarboxylate 4.Reduction and p-fluorobenzoylation of 4 led to the primary alcohols 7.The alcohols were tr

Full text of DOI:10.1016/S0040-4020(01)81192-3

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