Synthesis of (+)-endo- and (+)-exo-brevicomin viaenzyme-mediated hydrolysis of an enol ester

Article abstract of DOI:10.1016/S0040-4039(00)97268-X

Optically pure (+)-endo- and (+)-exo-brevicomin have been synthesized in short steps starting from α-hydroxy ketone derivative, (R)-4-benzyloxy-8-nonen-3-one (3), which was prepared via enzymatic hydrolysis of racemic enol ester 4.