Easy Access to 5-Alkyl-4-bromo-2(5H)-furanonens: Synthesis of a Fimbrolide, an Acetoxyfimbrolide, and Bromobeckerelide

Article abstract of DOI:10.1021/jo00111a045

Treatment of γ-monosubstituted allenic esters with N-bromosuccinimide in water yields 5-alkyl-4-bromo-2(5H)-furanones, that can be transformed into 4-alkylidene-4-bromo-2(5H)-furanones in good overall yields.Starting with a simple allenic ester these tran