Journal of Organic Chemistry p. 1537 - 1542 (1991)
Update date:2022-08-03
Topics:
Qi, Zhihong Helena
Mak, Vivien
Diaz, Luis
Grant, David M.
Chang, Ching-jer
Specific molecular recognition between α-cyclodextrin (1) and a β-lactam antibiotic, penicillin V (2), was systematically determined.A stable 1:1 inclusion complex was established in the solid state, gaseous phase, and solution.The distinct structure of this inclusion complex was rigorously elucidated by FT-IR, FAB-MS, CP/MAS solid state 13C NMR, and 500-MHz 1H NMR.Based on strictly determined 1H NMR data, a time-averaged conformation of the α-CD-penicillin V inclusion complex was proposed, which was supported by CPK model studies and the intermolecular NOE results.Moreover, α-cyclodextrin exhibited significant catalytic activity toward the hydrolysis of penicillin V in weakly alkyline solution.These findings imply that the initial molecular recognition and the concomitant molecular association are essential in a biomimetic process.
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