Remarkable difference of chemoselectivity in the reduction of α-bromo ketones with dibutyltin dihydride system

Article abstract of DOI:10.1016/S0040-4039(00)97070-9

Remarkably different chemoselectivities were noted in the reduction of α-bromo ketones by n-Bu₂SnH₂ system. Without additive, the reduction of α-bromo group took place. While, the addition of small amounts of p-Dinitrobenzene (DNB) caused the chemoselective reduction of carbonyl group.