Tetrahedron p. 559 - 572 (1994)
Update date:2022-07-29
Topics:
Andersson
Nilsson
Backvall
Palladium-catalyzed oxidation of 1-(3-hydroxyalkyl) and 1-(4- hydroxyalkyl)-1,3-cycloalkadienes results in a stereocontrolled oxaspirocyclization. The reaction proceed via a spirocyclic (π- allyl)palladium intermediate, which is attacked by an acetate or a chloride nucleophile leading to an overall 1,4-addition across the diene. The intermediate (π-allyl) palladium complex was independently prepared and characterized. The stereochemistry of the 1,4-addition can be controlled to give either cis or trans 1,4-addition across the double bonds. The oxaspirocyclization was applied to the total synthesis of theaspirone.
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