Regioselective Oxidation of Piperidine-3 Derivatives: A Synthetic Route to 2,5-Substituted Piperidines

DOI: 10.1021/jo00007a025

Source and publish data:

Journal of Organic Chemistry p. 2386 - 2390 (1991)

Update date:2022-08-03

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Authors:

Compernolle, Frans

Saleh, M. Ashty

Branden, Stefan Van den

Toppet, Suzanne

Hoornaert, Georges

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Article abstract of DOI:10.1021/jo00007a025

Mercuric acetate oxidation of 1-benzyl-3,3-(ethylenedioxy)piperidine (1) and of 3-CO2Et- and 3-CH2OH-substituted piperidines 7-9 was shown to occur regioselectively at the 6-position.Trapping of the resulting 6-iminium ions with cyanide yielded the corres

Full text of DOI:10.1021/jo00007a025

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