
Chemistry of Heterocyclic Compounds p. 1164 - 1167 (1990)
Update date:2022-08-04
Topics:
Garmash, S. N.
Skul'skaya, E. A.
Priimenko, B. A.
Klyuev, N. A.
Bromination of 2-aryloxazolo<3,2-f>xanthines gives the 3-bromoderivatives whereas 8-methyl-2-phenyloxazolo<3,2-f>xanthine is nitrated in the para-position of the phenyl substituent.Alkylation of oxazolo<3,2-f>xanthines by ethylmonoiodoacetate gives the ethyl esters of oxazolo<3,2-f>xanthinyl-6-acetic acids.Reaction of oxazolo<3,2-f>xanthines with sodium sulfide gives thiazolo<3,2-f>xanthines whereas the reaction with secondary amines opens the oxazole ring.
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