Cyclic RGD Peptide Analogues as Antiplatelet Antithrombotics

DOI: 10.1021/jm00089a014

Source and publish data:

Journal of Medicinal Chemistry p. 2040 - 2048 (1992)

Update date:2022-08-04

Topics:

Authors:

Barker, Peter L.

Bullens, Sherron

Bunting, Stuart

Burdick, Daniel J.

Chan, Kathryn S.

et al. et al.

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Article abstract of DOI:10.1021/jm00089a014

Stimulation of platelets activates GPIIbIIIa, the heterodimeric integrin receptor, to bind fibrinogen (Fg), which results in platelet aggregation.GPIIbIIIa/Fg binding inhibitors are potentially suitable for acute use during and after thrombolytic therapy

Full text of DOI:10.1021/jm00089a014

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