Conversion of Dipeptides and a Tetrapeptide to Macrocyclic Ionophores by means of Caesium Aided Ring Closure of the N-2-Chloroacetyl Derivatives

Article abstract of DOI:10.1039/c39900001647

Three di-, (Gly)2, (Val)2 and (Leu)2, and one tetrapeptide, (Gly)4, have been acylated with 2-chloroacetyl chloride and the resulting products treated with Cs2CO3 in the dimethylformamide (DMF) solution; (Gly)2 and (Leu)2 provided strained 9-membered rings whereas (Val)2 dimerized to the 18-membered ring.

Full text of DOI:10.1039/c39900001647

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