Indolizine derivatives with biological activity VI 1-(2-aminoethyl)-3-benzyl-7-methoxy-2-methylindolizine, benanserin structural analogue

Article abstract of DOI:10.1016/0223-5234(90)90138-S

In continuing the search for new biologically active agents in the indolizine field, 1-(2-aminoethyl)-3-benzyl-7-methoxy-2-methyl-indolizine was synthesized and evaluated for its in vitro activities on smooth muscle.Anti-histamine, anti-acetylcholine and anti 5-hydroxytryptamine activities, in comparison to those of the indole analogue benanserin, are reported.