A practical, one-pot preparation of diisopinocampheylchloroborane

Article abstract of DOI:10.1080/00397919108021071

A one-pot preparation of the chiral reducing agent diisopinocampheylchloroborane (Ipc₂BCl) from α-pinene and borane methyl sulfide has been developed. The procedure obviates isolation of the air and moisture sensitive reagent, making it useful for large scale operations. Asymmetric reduction of ketones using the in situ prepared Ipc₂BCl is comparable to that using isolated reagent.

Full text of DOI:10.1080/00397919108021071

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A Practical, One-
Pot Preparation of
Diisopinocampheylchloroborane
P. Simpson a , D. Tschaen a & T. R. Verhoeven a
a Merck Sharp and Dohme Research Laboratories ,
Division of Merck & Co., Inc. , P.O. Box 2000,
Rahway, N. J., 07065
Published online: 23 Sep 2006.
To cite this article: P. Simpson , D. Tschaen & T. R. Verhoeven (1991) A Practical,
One-Pot Preparation of Diisopinocampheylchloroborane, Synthetic Communications:
An International Journal for Rapid Communication of Synthetic Organic Chemistry,
21:15-16, 1705-1714, DOI: 10.1080/00397919108021071
To link to this article: http://dx.doi.org/10.1080/00397919108021071
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