Carbohydrate-derived partners display remarkably high stereoselectivity in aldol coupling reactions

Article abstract of DOI:10.1016/S0040-4020(01)80916-9

Aldol condensation between 3-keto and aldehyde sugars have been studied. The enolate 3 reacts with aldehydes preferentially from the β-face to give axial C2 condensation products. However, if the reaction conditions are not controlled properly some C2 epi