Highly Stereoselective Asymmetric Hydrogenation of 2-Benzamidomethyl-3-oxobutanoate catalysed by Cationic binap-Ruthenium(II) Complexes

DOI: 10.1039/c39910000609

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 609 - 610 (1991)

Update date:2022-09-26

Topics:

Authors:

Mashima, Kazushi

Matsumura, Yoh-ichi

Kusano, Koh-hei

Kumobayashi, Hidenori

Sayo, Noboru

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1039/c39910000609

Highly diastereoselective hydrogenation of methyl 2-benzamidomethyl-3-oxobutanoate has been accomplished by using (p-cymene)>I and corresponding complexes of derivatives of binap as catalyst, giving methyl (2S,3R)-2-benzamidomethyl-3-hydroxybutanoate, a versatile intermediate for the synthesis of β-lactam antibiotics, in up to 98percent diastereoisomeric excess and 99percent enantiomeric excess.

Full text of DOI:10.1039/c39910000609

View Article Online / Journal Homepage / Table of Contents for this issue

View Article Online

Products guided by the article

Product name:{RuI((S)-2,2'-bis(bis(3-methylphenyl)phosphino)-1,1'-binaphthyl)(p-cymene)}I

Cas No:133078-49-6

R&D Labs maybe for 133078-49-6

Landz International Company Ltd.

Contact:0086-21-58891610

Address:985 Dongfang Road, Pudong, Shanghai 200122 China
SJZ THLD IMP & EXP CO LTD

website:http://www.truewingroup.com

Contact:86-311-66699812

Address:NO.600 ZHONGSHAN EAST ROAD SHIJIAZHUANG
Oceachem Group Limited

website:http://www.oceanchem-group.com

Contact:86-536-8596048

Address:9th floor,Building B future Plaza, No.88.Fenghuang Street,Weifang,Shandong,China
Hangzhou Zyter Biological & Chemical Technology Co., Ltd.

website:http://www.zyterpharm.com

Contact:+86-18858184290

Address:West Wenyi Road, Cangqian, Yuhang
ZUNYI CITY BEI YUAN CHEMICAL CO., LTD

website:http://www.china-beiyuan.com

Contact:+86-851-27751258

Address:Shawan Town, Huichuan District, Zunyi City, Guizhou Province, China

Relevant to this article

Synthesis and activity evaluation of a new bestatin derivative LYP2 as an aminopeptidase N inhibitor

Doi:10.1097/CAD.0b013e32833ab78a
(2011)
1,4-Di-o-tolyl-2,3-naphthoquinone

Doi:10.1039/c39830000703
(1983)
Copper-Catalyzed Synthesis of α-Trifluoromethylacrylates from Trifluoroborylacrylates via Stereoretentive Radical Trifluoromethylation

Doi:10.1002/adsc.202000937
(2021)
Formation of a cyclic bis(iminophosphorane) from a 2,2′- bis(phosphino)azobenzene via N=N bond cleavage

Doi:10.1002/hc.20680
(2011)
DNA-mediated assembly of cytochrome P450 BM3 subdomains

Doi:10.1021/ja204993s
(2011)
ELECTROREDUCTIVE CYCLIZATION REACTIONS: ATTEMPTS TO USE 2(5H)FURANONES (α,β-UNSATURATED BUTENOLIDES). DOMINANCE OF ACID-BASE OVER CYCLIZATION CHEMISTRY

Doi:10.1016/S0040-4020(01)90497-1
(1991)

Article Doi