Highly Stereoselective Asymmetric Hydrogenation of 2-Benzamidomethyl-3-oxobutanoate catalysed by Cationic binap-Ruthenium(II) Complexes

DOI: 10.1039/c39910000609

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 609 - 610 (1991)

Update date:2022-09-26

Topics:

Authors:

Mashima, Kazushi

Matsumura, Yoh-ichi

Kusano, Koh-hei

Kumobayashi, Hidenori

Sayo, Noboru

et al. et al.

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Article abstract of DOI:10.1039/c39910000609

Highly diastereoselective hydrogenation of methyl 2-benzamidomethyl-3-oxobutanoate has been accomplished by using (p-cymene)>I and corresponding complexes of derivatives of binap as catalyst, giving methyl (2S,3R)-2-benzamidomethyl-3-hydroxybutanoate, a versatile intermediate for the synthesis of β-lactam antibiotics, in up to 98percent diastereoisomeric excess and 99percent enantiomeric excess.

Full text of DOI:10.1039/c39910000609

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