A Chiral Building Block with Bicyclooctanone Skeleton by the Reduction with Baker's Yeast

Article abstract of DOI:10.1016/S0957-4166(00)80443-7

Preparation of functionalized bicyclo<2.2.2>octan-2-one with high optical purity is described.Reduction of a bridged diketone 2 with baker's yeast gave an endo-hydroxyketone (+)-12 of 98.5-99.5percent e.e. in 91percent yield.X-ray crystallography of its (